Established in 2005 under the impetus of the AFM-Telethon and Inserm, I-stem is dedicated to research on stem cells for the treatment and study of monogenic diseases.


The Institute for Stem Cell Therapy and Exploration of Monogenic diseases (I-stem) is a research and development centre of international reference dedicated to the development of treatments based on the potential offered by pluripotent stem cells (ECs and iPS) and applicable to rare diseases of genetic origin. Its objective is to promote these approaches from their development to clinical research.



  • Research and development: stem cells biotechnology; high throughput screening; disease modelling; development of tools for the study of monogenic diseases.
  • Cell therapy and disease modelling: neurodegenerative diseases, genodermatoses, neuromuscular diseases, retinopathies, motor neuron diseases, neurovascular injuries…

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I-Stem laboratories have 80 employees and are located in Evry (Essonne).


Summary of activities

Synthèse d’activités 2020 (French)