{"id":5536,"date":"2016-04-29T16:29:58","date_gmt":"2016-04-29T14:29:58","guid":{"rendered":"https:\/\/www.institut-biotherapies.fr\/en\/?p=5536"},"modified":"2016-04-29T16:32:01","modified_gmt":"2016-04-29T14:32:01","slug":"aire-key-factor-in-the-gender-inequality-for-autoimmune-diseases","status":"publish","type":"post","link":"https:\/\/www.institut-biotherapies.fr\/en\/2016\/04\/29\/aire-key-factor-in-the-gender-inequality-for-autoimmune-diseases\/","title":{"rendered":"AIRE, key factor in the gender inequality for autoimmune diseases"},"content":{"rendered":"
\"Sonia

Sonia Berrih-Aknin, researcher at the Institute of Myology<\/p><\/div>\n

Nadine Dragin, researcher among an Inserm\/UPMC\/CNRS (French National Center for Scientific Research)\/Institute of Myology team co-directed by Sonia Berrih-Aknin and Rozen le Panse from the Institute of Myology<\/a>, based in the Piti\u00e9-Salp\u00eatri\u00e8re Hospital, AP-HP, brought to light the central role of AIRE, a key factor for immune tolerance, in the gender inequality regarding autoimmune diseases.<\/p>\n

To prove this inequality, the researchers from the Institute of Myology looked into the mechanisms of thymic tolerance, meaning a state of immune non-response while facing an antigen. The research teams then observed that Auto-Immune Regulator (AIRE), key factor in the immune tolerance, is less expressed for women than for men. Moreover, the researchers showed that estrogen was the hormone responsible for the decrease of the AIRE expression in thymic cells.<\/p>\n

This set of results reveals that, for women, estrogen leads to changes in the AIRE gene expression, thus increasing women\u2019s susceptibility to autoimmune diseases. Therefore, the AIRE expression levels can indicate a predisposition to an autoimmune disease and turn the estrogen level into a potential therapeutic target.<\/p>\n

\"Rozen

Rozen Le Panse, researcher at the Institute of Myology<\/p><\/div>\n

This work, published on Avril 1st, 2016 in The Journal of Clinical Investigation were supported by AFM-T\u00e9l\u00e9thon<\/a> and are available online<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Nadine Dragin, researcher among an Inserm\/UPMC\/CNRS (French National Center for Scientific Research)\/Institute of Myology team co-directed by Sonia Berrih-Aknin and Rozen le Panse from the Institute of Myology, based in the Piti\u00e9-Salp\u00eatri\u00e8re Hospital, AP-HP, brought to light the central role of AIRE, a key factor for immune tolerance, in the gender inequality regarding autoimmune diseases. … [Read more]<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,9],"tags":[],"class_list":["post-5536","post","type-post","status-publish","format-standard","hentry","category-news","category-press-releases"],"_links":{"self":[{"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/posts\/5536","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/comments?post=5536"}],"version-history":[{"count":3,"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/posts\/5536\/revisions"}],"predecessor-version":[{"id":5541,"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/posts\/5536\/revisions\/5541"}],"wp:attachment":[{"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/media?parent=5536"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/categories?post=5536"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/tags?post=5536"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}