{"id":4358,"date":"2012-12-13T15:44:20","date_gmt":"2012-12-13T13:44:20","guid":{"rendered":"https:\/\/www.institut-biotherapies.fr\/?page_id=4358"},"modified":"2012-12-13T15:44:20","modified_gmt":"2012-12-13T13:44:20","slug":"crigler-najjar-disease","status":"publish","type":"page","link":"https:\/\/www.institut-biotherapies.fr\/en\/liver-diseases\/crigler-najjar-disease\/","title":{"rendered":"Crigler-Najjar disease"},"content":{"rendered":"<p>Crigler-Najjar disease is a rare genetic disease of the liver leading to neurologic complications due to the neurotoxicity of non-conjugated bilirubin. Symptomatic treatment of the disease consists in daily phototherapy for 10 to 12 hours.<\/p>\n<h2>Pre-clinical study for a gene therapy treatment<\/h2>\n<ul>\n<li><strong>Reference laboratory<\/strong>: Genethon<\/li>\n<\/ul>\n<p>This development project currently at the pre-clinical stage is based on direct administration of an AAV (Adeno-Associated Virus) vector carrying a normal copy of the gene which is mutated in patients. It is being performed in collaboration with Dr. Philippe Labrune (AP-HP, Antoine B\u00e9cl\u00e8re Hospital in Clamart) and Dr. Piter Bosma (AMC Amsterdam Academic Medical Center, Tytgat Institute in Amsterdam).<\/p>\n<p><a title=\"Genethon : Crigler-Najjar Syndrome\" href=\"http:\/\/www.genethon.fr\/en\/products\/other-products\/crigler-najjar-syndrome\/\" target=\"_blank\">For more information: the pre<strong>&#8211;<\/strong>clinical study for a gene therapy treatment for Crigler-Najjar syndrome<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Crigler-Najjar disease is a rare genetic disease of the liver leading to neurologic complications due to the neurotoxicity of non-conjugated bilirubin. Symptomatic treatment of the disease consists in daily phototherapy for 10 to 12 hours. Pre-clinical study for a gene therapy treatment Reference laboratory: Genethon This development project currently at the pre-clinical stage is based &hellip; <a href=\"https:\/\/www.institut-biotherapies.fr\/en\/liver-diseases\/crigler-najjar-disease\/\">[Read more]<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":4356,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-4358","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/pages\/4358","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/comments?post=4358"}],"version-history":[{"count":0,"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/pages\/4358\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/pages\/4356"}],"wp:attachment":[{"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/media?parent=4358"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}