{"id":4327,"date":"2012-12-13T15:13:41","date_gmt":"2012-12-13T13:13:41","guid":{"rendered":"https:\/\/www.institut-biotherapies.fr\/?page_id=4327"},"modified":"2012-12-13T15:13:41","modified_gmt":"2012-12-13T13:13:41","slug":"severe-combined-immune-deficit","status":"publish","type":"page","link":"https:\/\/www.institut-biotherapies.fr\/en\/blood-disorders\/severe-combined-immune-deficit\/","title":{"rendered":"Severe combined immune deficit"},"content":{"rendered":"<p>This very rare primary immune deficit is caused by mutation of the Artemis gene and is characterized by a complete absence of T and B lymphocytes associated with increased cellular sensitivity to ionizing radiations. The only treatment is a bone marrow graft from a compatible donor.<em> <\/em><\/p>\n<h2>Development program for a gene therapy trial<\/h2>\n<ul>\n<li><strong>Reference laboratory<\/strong>: Genethon<\/li>\n<\/ul>\n<p>The program for the development of gene therapy is based on the construction of a lentiviral vector expressing the Artemis gene at levels which are efficient and non-toxic in stem cells and in the immune system of patients. Preclinical studies and the construction of the clinical vector are carried out at Genethon in collaboration with Professor Hacein-Bey Abina and Dr. Cavazzana-Calvo (CIC Biotherapie, Hopital Necker-Enfants Malades), with financial support from INSERM\/DGOS.<\/p>\n<p><a title=\"Genethon : Radiosensitive Severe Combined Immunodeficiency (Artemis gene mutation)\" href=\"http:\/\/www.genethon.fr\/en\/products\/other-products\/severe-combined-immunodeficiency\/\" target=\"_blank\">For more information: development program for a gene therapy trial<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This very rare primary immune deficit is caused by mutation of the Artemis gene and is characterized by a complete absence of T and B lymphocytes associated with increased cellular sensitivity to ionizing radiations. The only treatment is a bone marrow graft from a compatible donor. Development program for a gene therapy trial Reference laboratory: &hellip; <a href=\"https:\/\/www.institut-biotherapies.fr\/en\/blood-disorders\/severe-combined-immune-deficit\/\">[Read more]<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":4321,"menu_order":30,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-4327","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/pages\/4327","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/comments?post=4327"}],"version-history":[{"count":0,"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/pages\/4327\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/pages\/4321"}],"wp:attachment":[{"href":"https:\/\/www.institut-biotherapies.fr\/en\/wp-json\/wp\/v2\/media?parent=4327"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}